Daily Dose Q&A
2025-11-19
Buspirone is a commonly prescribed anxiolytic. Many people with anxiety also consume cannabis to treat their symptoms. Could the metabolism of buspirone be impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes buspirone, and therefore the co-administration of THC and buspirone may result in an increased availability of buspirone.2025-11-18
Haloperidol is an antipsychotic medication and used to treat schizoaffective disorders and schizophrenia. Is the metabolism of haloperidol impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes haloperidol, and therefore the co-administration of THC and haloperidol may result in an increased availability of haloperidol.2025-11-17
Does CBD alter the metabolism of methadone?
Yes. Cannabidiol inhibits CYP3A4 and CYP2C19, both of which are involved in the metabolism of methadone. As a result, the co-administration of CBD and methadone may lead to increased sedation.Madden K, Tanco K, Bruera E. Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol.Pediatrics May 2020; e20193256;
2025-11-14
Fluoxetine, like sertraline, is an SSRI and used to treat depression and sometimes OCD. Could the metabolism of fluoxetine be impacted by THC?
Yes, THC inhibits CYP3A4 and CYP2C9, the enzymes that metabolize fluoxetine, and therefore the co-administration of THC and fluoxetine may result in an increased availability of fluoxetine.Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021.
2025-11-13
Sertraline is a commonly prescribed selective serotonin reuptake inhibitor (SSRI) to treat depression, anxiety, OCD, PTSD and/or other ailments. Many people with depression, anxiety, OCD and/or PTSD also consume cannabinoid-based medicines to treat their symptoms. Could the metabolism of sertraline be impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes sertraline, and therefore the co-administration of THC and sertraline may result in an increased availability of sertraline.Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021.