Daily Dose Q&A
2025-11-25
CBD oil products may be sold as full spectrum, broad spectrum, CBD isolate and whole plant CBD. What is the difference among the four types? 
Full spectrum CBD extract contains CBD and other cannabinoids (including up to 0.3% THC), terpenes, and essential oils. Unlike full spectrum CBD, broad spectrum CBD does not contain THC, but it does contain the other components found in full spectrum CBD. CBD isolate is CBD in its molecular form, and is typically sold as 99+% pure. Whole plant CBD is similar to, but not the same as full spectrum CBD. Whole plant and full spectrum CBD contain a variety of cannabinoids; however, whole plant CBD will also contain fats, waxes, and other fibrous materials.Norton M. To CBD or not to CBD?: What Pharmacists need to know. Pharmacy Today. AUG O1,2020; VOLUME 26, ISSUE 8: P41-55.
2025-11-24
Do oral mucosal spray cannabinoid-based medicines (CBMs) have the same bioavailability as ingested CBMs?
No. The administration of CBMs via oromucosal sprays (sublingual) avoids first-pass metabolism (although some of the product is swallowed) and therefore sublingual administration has a higher bioavailability than ingested formulations.Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,
2025-11-21
True or false? Patients who are allergic to cherries, tangerines, peaches, tomatoes, hazelnuts, latex and/or tobacco may also be allergic to cannabis products.
True. These listed fruits and vegetables have proteins that are similar to the ones found in cannabis. As a result, cross-sensitivity may occur, and a patient who is allergic to one of the products listed may develop an allergic reaction to a cannabis product.Jackson, B., Cleto, E., & Jeimy, S. (2020). An emerging allergen: Cannabis sativa allergy in a climate of recent legalization. Allergy, Asthma & Clinical Immunology, 16(1). https://doi.org/10.1186/s13223-020-00447-9
2025-11-20
Is the bioavailability of THC greater with inhaled cannabinoid-based medicines (CBMs) or ingested CBMs?
The bioavailability of inhaled CBMs is nearly 30% while the bioavailability of ingested CBMs is approximately 4%-20%. (It should be noted that the bioavailability is higher with vaporized cannabis as compared with combusted (smoked) cannabis products.)Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,
2025-11-19
Buspirone is a commonly prescribed anxiolytic. Many people with anxiety also consume cannabis to treat their symptoms. Could the metabolism of buspirone be impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes buspirone, and therefore the co-administration of THC and buspirone may result in an increased availability of buspirone.Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,