Daily Dose Q&A

2026-03-04

What are the effects of acute use of marijuana on male libido?

"Studies support that male libido may be augmented after acute use, but there are reports of erectile dysfunction with chronic use."

Meah F, Lundholm M, Emanuele N, Amjed H, Poku C, Agrawal L, Emanuele MA. The effects of cannabis and cannabinoids on the endocrine system. Rev Endocr Metab Disord. 2022 Jun;23(3):401-420. doi: 10.1007/s11154-021-09682-w. Epub 2021 Aug 30. PMID: 34460075.

2026-03-03

Does the consumption of cannabinoid-based products impact breastfeeding?

Yes. Cannabinoids bind to cannabinoid 1 receptors in the hypothalamus which triggers a release of dopamine. The dopamine, in turn, inhibits release of prolactin from the anterior pituitary. Prolactin is necessary for lactation. Cannabis consumption may not completely stop the production of breastmilk, and breastmilk produced by women who consume cannabis-based products may contain cannabinoids.

2026-03-02

Anecdotal evidence supports the use of haloperidol for the treatment of cannabinoid hyperemesis syndrome (CHS). Is haloperidol more effective than ondansetron for the treatment of the nausea and vomiting associated with CHS?

According to the results of a randomized controlled trial involving 33 patients with cannabinoid hyperemesis syndrome, haloperidol (0.05 mg/kg or 0.1 mg/kg) was superior to ondansetron 8mg for average reduction from baseline in abdominal pain and nausea at 2 hours, and was associated with the need for fewer rescue antiemetics and shorter time to ED departure. In this study, there were 2 haloperidol and 6 ondansetron return ED visits for ongoing nausea/vomiting, as well as 2 return visits for acute dystonia, both in the higher dose haloperidol group.

Ruberto, A., Sivilotti, M., Forrester, S., Hall, A., Crawford, F., & Day, A. (2020). LO69: Haloperidol versus ondansetron for hyperemesis due to cannabis (HaVOC): A randomized, controlled clinical trial. CJEM, 22(S1), S32-S33. doi:10.1017/cem.2020.124

2026-02-27

THC, CBD and CBN can inhibit the hydroxylation of warfarin and increase the INR. Do cannabinoids affect the metabolism of heparin? Is the metabolism of direct oral anticoagulants (rivaroxaban, edoxaban, apixaban) impacted by cannabinoids?

While cannabinoids do not alter the metabolism of heparin, cannabinoids may impact the metabolism of DOACs. DOAC levels may increase, leading to an increased risk of bleeding.

Greger J, Bates V, Mechtler L, Gengo F. A Review of Cannabis and Interactions With Anticoagulant and Antiplatelet Agents. J Clin Pharmacol. 2020 Apr;60(4):432-438. doi: 10.1002/jcph.1557. Epub 2019 Nov 13. PMID: 31724188..

2026-02-26

Does marijuana use alter the sexual intercourse experience?

An online survey posed questions regarding various aspects of sexual experience and how those aspects were impacted by marijuana use. The results indicated that marijuana helped individuals relax, heightened their sensitivity to touch, and increased intensity of feelings, thus enhancing their sexual experience, while others found that marijuana interfered by making them sleepy and less focused or had no effect on their sexual experience.

Wiebe E, Just A. How Cannabis Alters Sexual Experience: A Survey of Men and Women. J Sex Med 2019;