Your Dose of Cannabis Education

Your Dose of Cannabis Education

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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education. 

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2025-10-30
Are cannabinoids absorbed to the same extent with smoking compared to vaporizing?
No. When ingesting marijuana via a vaporizer, the user absorbs up to 33% of the total cannabinoids present in herbal mixture. When smoking, an individual typically absorbs about 25% of the cannabinoids present in herbal mixture.
Peters J, Chien J. Contemporary Routes of Cannabis Consumption: A Primer for Clinicians. The Journal of the American Osteopathic Association, February 2018, Vol. 118, 67-70. doi: https://doi.org/10.7556/jaoa.2018.020.
2025-10-29
CBD-related liver enzyme elevations and drug-induced liver injury (DILI) have been observed at doses ≥20 mg/kg/day, especially with valproate co-administration. However, DILI was not reported at doses <300 mg/day. Is the risk of DILI significantly greater with CBD as compared to with statins?
Actually, no. The risk of DILI is comparable to or even slightly lower with CBD as compared to with statins or fluoroquinolones.
Lo, LA, Christiansen, A, Eadie, L, Strickland, JC, Kim, DD, Boivin, M, et al. Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis. J Intern Med. 2023; 293: 724– 752.
2025-10-28
Does abrupt discontinuation of CBD use lead to a withdrawal syndrome?
No. In a study evaluating abuse liability of CBD, it was found that “abrupt withdrawal of CBD after 4 weeks of use (750 mg twice daily taken orally) did not result in any symptoms of physical withdrawal.” Unlike THC, CBD is not addictive.
Kirkland AE, Fadus MC et al.. A scoping review of the use of cannabidiol in psychiatric disorders. Psych Resear. 308 (2022)
2025-10-27
Clinical trials are evaluating the use of CBD for the treatment of various psychological conditions. What are some of the psychological conditions being studied?
The specific psychological health conditions for which CBD is being evaluated include schizophrenia and bipolar disorder, adjunct treatment in early psychosis, anxiety and insomnia, treatment-resistant depression, PTSD (CBD+THC), ADHD (CBD+THC), and panic disorder. Also, use disorders, including cannabis use disorder, alcohol use disorder, and opioid use disorder are being studied.
Clinicaltrials.gov
2025-10-24
What are the mechanisms by which THC and CBD impact pain sensation?
According to a British Medical Journal (BMJ) article, "THC inhibits glutamate and 5-hydroxytryptamine release and increases dopamine secretion. CBD enhances adenosine receptor signaling, and decreases reactive oxygen species, tumour necrosis factor, and T cell proliferation, without the psychoactive effects of THC. The multifaceted analgesic and anti-inflammatory properties of cannabinoids may positively influence the perception of pain across different conditions." (BMJ)
Busse JW, Vankrunkelsven P, Zeng L, et al. Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline. BMJ. 2021;374:n2040. doi:10.1136/bmj.n2040

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