Your Dose of Cannabis Education
Your Dose of Cannabis Education
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2025-08-28
The receptors of the endocannabinoid system (ECS) are found throughout the central and peripheral nervous systems. Are ECS receptors also found on non-nerve cells? 
Yes. CB2 receptors are found throughout the immune system. They are present on B cells, T cells, and macrophages. Also, CB2 receptors are expressed on cells of the spleen, liver, kidneys and skin. Slawek DE, Curtis SA, Arnsten JH, and Cunningham CO. Clinical Approaches to Cannabis: A Narrative Review. Med Clin N Am 106 (2022) 131-152.
2025-08-27
Are cannabinoid receptors found in organs involved with the production of sex hormones?
Cannabinoid-1 (CB1) receptors are found throughout the central nervous system and some peripheral tissues. Canabinoid-2 (CB2) receptors are mainly found in peripheral tissues and immune cells. Cannabinoid receptors are also present on the adrenals, (a source of androgens), and the ovaries, (a source of estrogen, progesterone, and androgens). In addition, CB receptors are present on oocytes and the uterus.Marcu I, Gee A, Lynn B. Cannabinoids and chronic pelvic pain in women: Focus on endometriosis. Journal of Endometriosis and Pelvic Pain Disorders. 2021;13(3):155-165. https://journals.sagepub.com/doi/abs/10.1177/22840265211011277?journalCode=peva
2025-08-26
What are the most common target symptoms for which multiple sclerosis (MS) patients use cannabinoid-based products?
According to a survey of 1,012 MS patients conducted through the "North American Research Committee on Multiple Sclerosis (NARCOMS) Global Multiple Sclerosis Registry: A Long-Term Study to Facilitate Research in Multiple Sclerosis," the most common target symptoms for which patients used cannabis were: spasticity (80%), pain (69%), and sleep (61%). The most preferred composition of cannabis-based products were: 50:50 THC:CBD (31%) and high THC/low CBD (30%).Cannabis Use Common Among People With MS
Ń Most don't ask for medical guidance, survey shows. https://www.medpagetoday.com/meetingcoverage/cmsc/95315
2025-08-25
What is Nabilone? What is the recommended dosage of Nabilone?
Nabilone is a synthetic cannabinoid that is similar in structure to delta-9-THC and is for oral administration. Nabilone is used for the treatment of chemotherapy-induced nausea and vomiting. As per the package insert, the usual dose of nabilone is 1 or 2 mg twice daily. The initial dose should be administered 1Đ3 hours before chemotherapy. Nabilone may be administered daily during the entire chemotherapy cycle 2 or 3 times/day. It is suggested to initiate nabilone therapy with the lower dosage of 1 mg twice daily to minimize adverse effects, and then increase the dose as needed up to a maximum of 2 mg 3 times/day. A dose of 1 or 2 mg may be administered the night prior to chemotherapy.Valeant Pharmaceuticals International. Cesamet (nabilone) capsules prescribing information. Costa Mesa, CA; 2006 Jul. https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/018677s011lbl.pdf
2025-08-22
What is the recommended dosage of dronabinol?
For adult patients with AIDS, the recommended adult starting dosage of dronabinol is 2.5 mg orally twice daily, one hour before lunch and dinner. For adult patients with n/v associated with chemotherapy, the recommended starting dosage is 5 mg/m2, administered 1 to 3 hours prior to the administration of chemotherapy, then every 2 - 4 hrs. after chemotherapy, for a total of 4 to 6 doses per day. (Beyond this dose, the risk of adverse effects may increase.) It is suggested that the first dose be administered on an empty stomach at least 30 minutes prior to eating; subsequent doses can be taken without regard to meals.Highlights of Prescribing Information of Marinol. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf
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