Your Dose of Cannabis Education

Your Dose of Cannabis Education

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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education. 

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2025-10-07
Propofol is an anesthetic agent used during monitored anesthesia care, as an induction agent for general anesthesia and commonly utilized in the intensive care unit for sedation of mechanically ventilated patients. Does propofol interact with the endocannabinoid system?
Yes, it does. Propofol inhibits the activity of fatty acid amide hydrolase (FAAH), the enzyme that degrades the endocannabinoid anandamide.
Daniela Hauer, Patrizia Ratano, Maria Morena, Sergio Scaccianoce, Isabel Briegel, Maura Palmery, Vincenzo Cuomo, Benno Roozendaal, Gustav Schelling, Patrizia Campolongo; Propofol Enhances Memory Formation via an Interaction with the Endocannabinoid System. Anesthesiology 2011; 114:1380-1388
2025-10-06
What is the pharmacokinetic profile of marijuana when it is administered orally?
The psychoactive and physiological effects of orally consumed marijuana typically appear approximately 90 minutes after ingestion, reach their maximum after 2-3 hours and last for about 4-12 hours. However, there is a heterogeneous response to oral marijuana consumption and some individuals may not appreciate the peak effect until 6 hours after consumption.
Grotenhermen F. Clinical pharmacokinetics of cannabinoids. J Cannabis Ther, 2003; 3(1): 3-51. https://www.tandfonline.com/doi/abs/10.1300/J175v03n01_02
2025-10-03
Fluoxetine (sold under the name Prozac) is a commonly prescribed antidepressant of the selective serotonin reuptake inhibitor class. Does Fluoxetine impact the metabolism of CBD?
Yes. Fluoxetine inhibits some of the liver enzymes that metabolize CBD. As a result, there is an increase in bioavailability of CBD, and a possible increase of adverse effects associated with CBD consumption.
Brown JD, Winterstein AG. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use. J Clin Med. 2019;8(7):989. Published 2019 Jul 8. doi:10.3390/jcm8070989. https://pubmed.ncbi.nlm.nih.gov/31288397/
2025-10-02
Do cannabinoids modify the metabolism of theophylline?
Yes. The combination of smoked marijuana and theophylline may lead to a decrease in theophylline levels.
Jusko WJ, Gardner MJ, Mangione A, Schentag JJ, Koup JR, Vance JW (1979). Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. J Pharm Sci 68: 1358 - 1366.
2025-10-01
Are there any special considerations for patients who consume cannabinoid-based products and are undergoing plastic surgery?
Yes. On occasion, plastic surgeons administer medicines such as atropine and/or epinephrine during a procedure. Both of these medications can increase heart rate. Cannabinoids may potentiate the increase in heart rate.
Edalatpour A, Attaluri P, Larson JD. Medicinal and Recreational Marijuana: Review of the Literature and Recommendations for the Plastic Surgeon. Plast Reconstr Surg Glob Open. 2020 May 29;8(5):e2838. doi: 10.1097/GOX.0000000000002838. PMID: 33133899; PMCID: PMC7572176.

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