Your Dose of Cannabis Education

Your Dose of Cannabis Education

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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education. 

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2025-11-21
True or false? Patients who are allergic to cherries, tangerines, peaches, tomatoes, hazelnuts, latex and/or tobacco may also be allergic to cannabis products.
True. These listed fruits and vegetables have proteins that are similar to the ones found in cannabis. As a result, cross-sensitivity may occur, and a patient who is allergic to one of the products listed may develop an allergic reaction to a cannabis product.
Jackson, B., Cleto, E., & Jeimy, S. (2020). An emerging allergen: Cannabis sativa allergy in a climate of recent legalization. Allergy, Asthma & Clinical Immunology, 16(1). https://doi.org/10.1186/s13223-020-00447-9
2025-11-20
Is the bioavailability of THC greater with inhaled cannabinoid-based medicines (CBMs) or ingested CBMs?
The bioavailability of inhaled CBMs is nearly 30% while the bioavailability of ingested CBMs is approximately 4%-20%. (It should be noted that the bioavailability is higher with vaporized cannabis as compared with combusted (smoked) cannabis products.)
Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,
2025-11-19
Buspirone is a commonly prescribed anxiolytic. Many people with anxiety also consume cannabis to treat their symptoms. Could the metabolism of buspirone be impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes buspirone, and therefore the co-administration of THC and buspirone may result in an increased availability of buspirone.
Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,
2025-11-18
Haloperidol is an antipsychotic medication and used to treat schizoaffective disorders and schizophrenia. Is the metabolism of haloperidol impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes haloperidol, and therefore the co-administration of THC and haloperidol may result in an increased availability of haloperidol.
Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021,
2025-11-17
Does CBD alter the metabolism of methadone?
Yes. Cannabidiol inhibits CYP3A4 and CYP2C19, both of which are involved in the metabolism of methadone. As a result, the co-administration of CBD and methadone may lead to increased sedation.
Madden K, Tanco K, Bruera E. Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol.Pediatrics May 2020; e20193256;

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