Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2026-02-03
Is the endocannabinoid system present and active during fetal development?
The endocannabinoid system (ECS) plays a significant role in fetal development.
Cannabinoid receptors and the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), appear around gestational week 19 in humans and are thought to influence early behavioral and neurodevelopmental processes.
Evidence from animal studies demonstrates that CB1 receptors are functional during fetal development and contribute to the formation, growth, migration, and wiring of neuronal networks. Studies indicate that prenatal THC exposure can disrupt the maturation of dopamine, opioid, glutamate, and GABAergic neurotransmitter systems within brain regions involved with reward and motivation.Jansson, L. M., et al. (2018). Perinatal marijuana use and the developing brain. JAMA, 320(6), 545-546. https://doi.org/10.1001/jama.2018.8401
Malach, M., Kovalchuk, I., & Kovalchuk, O. (2022). Medical cannabis in pediatric oncology: Friend or foe? Pharmaceuticals, 15(3), 359. https://doi.org/10.3390/ph15030359
2026-02-02
If a patient is allergic to tomatoes, is there an increased likelihood that the patient is also allergic to cannabis products?
Yes. Patients with allergies to certain fruits and vegetables may also exhibit allergic reactions to cannabis-based products. Similar to other food-pollen and oral allergy syndromes, this cross-reactivity is believed to result from shared structural and antigenic features of non-specific lipid transfer proteins (nsLTPs) found in Cannabis sativa and in foods such as cherry, tangerine, peach, tomato, and hazelnut, as well as in latex and tobacco. These protein similarities can trigger immune cross-sensitization and subsequent allergic reactions upon exposure.Jackson, B., Cleto, E., & Jeimy, S. (2020). An emerging allergen: Cannabis sativa allergy in a climate of recent legalization. Allergy, Asthma & Clinical Immunology, 16(1), 1-5. https://doi.org/10.1186/s13223-020-00447-9
2026-01-30
How does cannabis consumption alter appetite and metabolism?
Cannabinoids influence both appetite and metabolism through CB1- and CB2-receptor pathways.
While CB1 activation increases appetite and promotes energy storage, it also reduces insulin secretion and may contribute to glucose intolerance.
Studies suggest that the endocannabinoid system modulates taste sensationdi Marzo, V., Piscitelli, F., & Mechoulam, R. (2011). Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. In M. Schwanstecher (Ed.), Diabetes - Perspectives in Drug Therapy (Handbook of Experimental Pharmacology, Vol. 203, pp. 75-104). Springer. https://doi.org/10.1007/978-3-642-17214-4_11
Farrimond, J. A., Mercier, M. S., Whalley, B. J., & Williams, C. M. (2011). Cannabis sativa and the endogenous cannabinoid system: Therapeutic potential for appetite regulation. Phytotherapy Research, 25(2), 170-188. https://doi.org/10.1002/ptr.3265
Matias, I., Bisogno, T., & di Marzo, V. (2006). Endogenous cannabinoids in the brain and peripheral tissues: Regulation of their levels and control of food intake. International Journal of Obesity, 30(Suppl. 1), S7-S12. https://doi.org/10.1038/sj.ijo.0803270
Tibirica, E. (2010). The multiple functions of the endocannabinoid system: A focus on the regulation of food intake. Diabetology & Metabolic Syndrome, 2, 5-10. https://doi.org/10.1186/1758-5996-2-5
2026-01-29
In adults, cannabis use is not typically associated with a decrease in respiratory drive. Is the same true for pediatric patients?
No - in the case of pediatric cannabis exposures, the common findings include confusion, agitation, lethargy, tachycardia, ataxia, and vomiting, BUT "more concerning findings are hypotension, coma, respiratory depression, and seizure, which occur in Pepin, L. C., Simon, M. W., Banerji, S., et al. (2023). Toxic tetrahydrocannabinol (THC) dose in pediatric cannabis edible ingestions. Pediatrics, 152(3), e2023061374. https://doi.org/10.1542/peds.2023-061374
2026-01-28
Is dizziness a common side effect of THC?
There is good evidence that dizziness is among the most common non-serious adverse neurological side-effects of medical cannabinoids. For example, a systematic review covering a 40-year span of studies found that dizziness occurred in 15.5% of patients exposed to cannabinoid therapy.Wang, T., Collet, J. P., Shapiro, S., & Ware, M. A. (2008). Adverse effects of medical cannabinoids: A systematic review. Canadian Medical Association Journal, 178(13), 1669-1678. https://doi.org/10.1503/cmaj.071178
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