Your Dose of Cannabis Education

Your Dose of Cannabis Education

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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education

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2026-02-05
What are the typical signs and symptoms of pediatric intoxication?
"Symptoms are usually nonspecific and include manifestations such as central nervous system depression (lethargy, coma), confusion, agitation, and ataxia. Nausea and vomiting, conjunctival hyperemia, mydriasis, tremors, speech difficulties, and behavioral disturbances are common. In episodes of severe intoxication, bradycardia, hypotension, convulsions, and respiratory depression have been reported, and may require orotracheal intubation." (Fradera) Although respiratory depression is not typical in adults, it may be present in pediatric patients.
Fradera, A. S., Campos, L. S., Profumo, A. D., et al. (2024). Accidental cannabis intoxication with an unexpected outcome. Emergencia Pediatricas, 3(2), 91-93.
2026-02-04
At what age is the human brain fully developed?
"The frontal lobes, the area of the brain responsible for 'executive functions' such as planning, working memory, and impulse control, are among the last areas of the brain to mature. They may not be fully developed until about age 25 years old. So, although many U.S. states have legalized recreational cannabis use for adults aged 21 years and older, it is important to note that the human brain is not fully developed, and individuals in their 20's may not realize the potentially significant long-term consequences of consuming cannabis.
Johnson, S. B., Blum, R. W., & Giedd, J. N. (2009). Adolescent maturity and the brain: The promise and pitfalls of neuroscience research in adolescent health policy. Journal of Adolescent Health, 45(3), 216-221.
2026-02-03
Is the endocannabinoid system present and active during fetal development?
The endocannabinoid system (ECS) plays a significant role in fetal development. Cannabinoid receptors and the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), appear around gestational week 19 in humans and are thought to influence early behavioral and neurodevelopmental processes. Evidence from animal studies demonstrates that CB1 receptors are functional during fetal development and contribute to the formation, growth, migration, and wiring of neuronal networks. Studies indicate that prenatal THC exposure can disrupt the maturation of dopamine, opioid, glutamate, and GABAergic neurotransmitter systems within brain regions involved with reward and motivation.
Jansson, L. M., et al. (2018). Perinatal marijuana use and the developing brain. JAMA, 320(6), 545-546. https://doi.org/10.1001/jama.2018.8401 Malach, M., Kovalchuk, I., & Kovalchuk, O. (2022). Medical cannabis in pediatric oncology: Friend or foe? Pharmaceuticals, 15(3), 359. https://doi.org/10.3390/ph15030359
2026-02-02
If a patient is allergic to tomatoes, is there an increased likelihood that the patient is also allergic to cannabis products?
Yes. Patients with allergies to certain fruits and vegetables may also exhibit allergic reactions to cannabis-based products. Similar to other food-pollen and oral allergy syndromes, this cross-reactivity is believed to result from shared structural and antigenic features of non-specific lipid transfer proteins (nsLTPs) found in Cannabis sativa and in foods such as cherry, tangerine, peach, tomato, and hazelnut, as well as in latex and tobacco. These protein similarities can trigger immune cross-sensitization and subsequent allergic reactions upon exposure.
Jackson, B., Cleto, E., & Jeimy, S. (2020). An emerging allergen: Cannabis sativa allergy in a climate of recent legalization. Allergy, Asthma & Clinical Immunology, 16(1), 1-5. https://doi.org/10.1186/s13223-020-00447-9
2026-01-30
How does cannabis consumption alter appetite and metabolism?
Cannabinoids influence both appetite and metabolism through CB1- and CB2-receptor pathways. While CB1 activation increases appetite and promotes energy storage, it also reduces insulin secretion and may contribute to glucose intolerance. Studies suggest that the endocannabinoid system modulates taste sensation
di Marzo, V., Piscitelli, F., & Mechoulam, R. (2011). Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. In M. Schwanstecher (Ed.), Diabetes - Perspectives in Drug Therapy (Handbook of Experimental Pharmacology, Vol. 203, pp. 75-104). Springer. https://doi.org/10.1007/978-3-642-17214-4_11 Farrimond, J. A., Mercier, M. S., Whalley, B. J., & Williams, C. M. (2011). Cannabis sativa and the endogenous cannabinoid system: Therapeutic potential for appetite regulation. Phytotherapy Research, 25(2), 170-188. https://doi.org/10.1002/ptr.3265 Matias, I., Bisogno, T., & di Marzo, V. (2006). Endogenous cannabinoids in the brain and peripheral tissues: Regulation of their levels and control of food intake. International Journal of Obesity, 30(Suppl. 1), S7-S12. https://doi.org/10.1038/sj.ijo.0803270 Tibirica, E. (2010). The multiple functions of the endocannabinoid system: A focus on the regulation of food intake. Diabetology & Metabolic Syndrome, 2, 5-10. https://doi.org/10.1186/1758-5996-2-5

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