Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2025-04-29
The FDA has approved a plant-derived purified CBD product for the treatment of 3 rare treatment-resistant epileptic disorders, including Lennox-Gastaut Syndrome (LGS). How effective is Epidiolex at reducing seizures in LGS patients? Does Epidiolex reduce seizures by 15%? By 30%? By > 45%? How long does the reduction of seizures last? 6 months? 1 year? Greater than 3 years? Besides a decrease in seizure activity, does Epidiolex positively impact health of the LGS in any other way? What dose was used to achieve these significant results?
"LGS patients who completed the Epidiolex RCTs were invited to enroll in a long-term open-label extension (OLE) trial… Patients received plant-derived highly purified CBD, titrated to a target maintenance dose of 20 mg/kg/day over 2 weeks. Based on response and tolerability, CBD could then be reduced or increased up to 30 mg/kg/day. Of 368 patients with LGS who completed the RCTs, 366 (99.5%) enrolled in this OLE. Median and mean treatment duration were 1090 and 826 days (range = 3–1421), respectively, with a mean modal dose of 24 mg/kg/day... Median percent reductions from baseline ranged 48%–71% for drop seizures and 48%–68% for total seizures through 156 weeks. Across all 12-week visit windows, 87% or more of patients/caregivers reported improvement in the patient's overall condition on the Subject/Caregiver Global Impression of Change scale."Patel AD, Mazurkiewicz-Bełdzińska M, Chin RF, Gil-Nagel A, Gunning B, Halford JJ, et al. Long-term safety and efficacy of add-on cannabidiol in patients with Lennox–Gastaut syndrome: Results of a long-term open-label extension trial. Epilepsia. 2021; 62: 2228–2239. https://doi.org/10.1111/epi.17000
2025-04-28
Does the consumption of CBD cause a significant change in the CBD consumers' self-perception of general health/overall well-being?
Yes, according to an observational study that examined the perceptions of long-term self-dosing CBD consumers, "CBD self-administration significantly improves self-perception of general health and decreases symptom severity, and as these improve, fewer OTC and Rx drugs are used." Kaufmann R, Bozer AH, Jotte AK, Aqua K. Long-Term, Self-Dosing CBD Users: Indications, Dosage, and Self-Perceptions on General Health/Symptoms and Drug Use. Med Cannabis Cannabinoids. 2023 Aug 16;6(1):77-88. doi: 10.1159/000531666. PMID: 37900894; PMCID: PMC10601936.
2025-04-25
What are the common symptoms of marijuana ingestion in young children?
"Common symptoms of marijuana ingestion in young children are drowsiness, somnolence, nausea, and vomiting, with children being at high risk for severe symptoms of respiratory depression and seizures." Zwiebel H, Greenky D, Goldman RD. Accidental cannabis ingestion in young children. Canadian Family Physician Mar 2025, 71 (3) 161-163; DOI: 10.46747/cfp.7103161.
2025-04-24
Does the use of CBD lead to a change in OTC and prescription drug consumption?
According to an observational study that examined the practices and perceptions of long-term self-dosing CBD adult consumers (age 18-75 years old), the use of CBD does lead to a change in OTC and prescription drug consumption. The findings of this observational study indicate that "the percentage of individuals decreasing or completely stopping OTC drugs or Rx drugs over the 4 weeks was 31.2% and 19.2%, respectively, with those taking CBD for chronic pain, decreasing drug use the most."Kaufmann R, Bozer AH, Jotte AK, Aqua K. Long-Term, Self-Dosing CBD Users: Indications, Dosage, and Self-Perceptions on General Health/Symptoms and Drug Use. Med Cannabis Cannabinoids. 2023 Aug 16;6(1):77-88. doi: 10.1159/000531666. PMID: 37900894; PMCID: PMC10601936.
2025-04-23
What is a typical daily dose of long-term self-dosing CBD consumers?
According to an observational study that examined the practices and perceptions of long-term self-dosing CBD adult consumers (age 18-75 years old), the mean daily dose was 53.1 mg/day, but the actual daily doses ranged from 8mg/day all the way up to 390 mg/day. (nearly a 50-fold difference). The median dose was 40.8 mg/day.Kaufmann R, Bozer AH, Jotte AK, Aqua K. Long-Term, Self-Dosing CBD Users: Indications, Dosage, and Self-Perceptions on General Health/Symptoms and Drug Use. Med Cannabis Cannabinoids. 2023 Aug 16;6(1):77-88. doi: 10.1159/000531666. PMID: 37900894; PMCID: PMC10601936.
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