Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2024-10-21
Does the oral administration of CBD alter plasma concentrations of diazepam?
CBD can alter the toxicity or efficacy of other drugs through inhibition of certain enzymes. For example, increases in the plasma concentration of diazepam have been reported when the diazepam is co-administered with Epidiolex (a CBD product). A Review of the Safety and Effectiveness of Select Ingredients in Compounded Topical Pain Creams."National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689. ×
2024-10-18
Is there a US governmental office to which patients can report any adverse effects from CBD products?
Yes, even though CBD (with the exception of Epidiolex) is not approved by the FDA, patients can report any adverse effects from CBD products to the FDA’s MedWatch program.Joshi K. Cannabis-derived compounds: What you need to know
Current Psychiatry. 2020 October;19(10):64-65 | 10.12788/cp.0050
2024-10-17
Does intravenous THC help ameliorate post-op nausea and vomiting (PONV)?
According to a double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV, intravenous THC does not ameliorate post-op nausea and vomiting (PONV). The results of the study indicated that "the relative risk reduction of overall PONV in the THC group was 12%, potentially less than the clinically significant 25% relative risk reduction demonstrated by other drugs used for PONV prophylaxis...Psychotropic THC side effects were clinically relevant [(mainly of sedation and confusion)] that were not tampered by the effects of anesthesia. The study was discontinued after 40 patients because of the inefficacy of THC against PONV and the finding of clinically unacceptable side effects that would impede the use of THC in the studied setting."Kleine-Brueggeney et al. Intravenous Delta-9-Tetrahydrocannabinol to Prevent Postoperative Nausea and Vomiting: A Randomized Controlled Trial. Anesth Analg 2015;121:1157–64.
2024-10-16
Have studies shown that patients are using medicinal cannabinoids as a substitute for prescription agents?
Yes, according to a systematic review and meta-analysis involving 27 studies, "The pooled percentage of the prevalence of substituting medical cannabis for one or more prescription drugs was 60.0%... Chronic pain and mental health conditions were prominent among the leading reasons for medical cannabis use. The most common substituted drug classes were narcotics/opioids, anxiolytics, and antidepressants." Of note, in this review "[m]ost results are mainly drawn from observational studies. Few good-quality randomized controlled trials (RCT) explore cannabis substitution effects."Veevarin Charoenporn, Thammanard Charernboon & Clare J Mackie (2022): Medical Cannabis as a Substitute for Prescription Agents: A Systematic Review and Meta-analysis, Journal of Substance Use, DOI: 10.1080/14659891.2022.2070870
2024-10-15
Has the use of topical CBD for the treatment of arthritis in the basal joint of the thumb been evaluated in CLINICAL trials?
Yes. The results of a study published in the May 27, 2022 edition of The Journal of Hand Surgery indicated that treatment with topical cannabidiol (CBD) 2x/day was associated with improvements in thumb basal joint arthritis-related pain and disability, and no adverse events were reported. This clinical study involved 18 participants with symptomatic thumb basal joint arthritis. The individuals were randomized to 2 weeks of CBD (6.2 mg/mL) with shea butter or only shea butter 2x/day. Then, there was a 1-week washout period, followed by 2 weeks with the other treatment. Treatment with CBD was associated with significant improvements in Visual Analog Scale (VAS) pain score, Disabilities of the Arm, Shoulder, and Hand (DASH) score, and Single Assessment Numeric Evaluation (SANE) scores from baseline compared with the control group (P <.05 for all). There were limitations of the study, including other interventions used among the study participants (for example, oral nonsteroidal anti-inflammatory drugs and/or acetaminophen, as needed), the small sample size of the study and short duration of treatment.Heineman JT, Forster GL, Stephens KL, Cottler PS, Timko MP, DeGeorge BR Jr. A randomized controlled trial of topical cannabidiol for the treatment of thumb basal joint arthritis. J Hand Surg Am. Published online May 27, 2022. doi:10.1016/j.jhsa.2022.03.002. https://www.jhandsurg.org/article/S0363-5023(22)00133-2/fulltext
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