Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2025-10-22
CB2 receptors are located in immune tissues and in peripheral tissues. What happens when CB2 receptors are activated? 
The activation of CB2 receptors results in various outcomes, including the inhibition of pro-inflammatory cytokine production and migration of immune cells (neutrophil and macrophages). As a result of these effects, chronic pain may be reduced.Chung M, Kim H, Abdi S. Update on cannabis and cannabinoids for cancer pain. Current Opinion in Anesthesiology. 2020, 33:825 – 831. https://pubmed.ncbi.nlm.nih.gov/33110020/ DOI:10.1097/ACO.0000000000000934
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2025-10-21
Is highly purified CBD a treatment opportunity for drug-resistant epilepsy in patients with typical Rett syndrome and CDKL5 deficiency disorder?
Possibly... A "study explored the use of highly purified Cannabidiol (CBD, Epidiolex) as an add-on therapy for individuals with drug- resistant epilepsy due to Rett Syndrome (RTT) or CDKL5 Deficiency Disorder (CDD). Twenty-seven participants received CBD alongside their usual ASMs [anti-seizure medications]. After a median treatment duration of 14 months, 66.6% experienced fewer seizures, with some showing over 75% reduction. Side effects were generally mild, mainly sleepiness or irritability. Notably, caregivers reported improvements in attention, responsiveness, sleep, and motor function. While results were not statistically significant, they suggest CBD may benefit seizure control and quality of life in RTT and CDD patients.Vignoli, A., Prato, G., Alfei, E., Bagnasco, I., Danieli, A., Celario, M., Favaro, J. et al. (2025). Is highly purified cannabidiol a treatment opportunity for drug-resistant epilepsy in subjects with typical Rett syndrome and CDKL5 deficiency disorder? Epilepsia Open, 00(0), 1-9. https://doi.org/10.1002/epi4.70078
2025-10-20
What are some of the more common reasons dermatologists recommend cannabinoid-based medicines?
According to the results of a survey of 145 dermatologists, 91 % of dermatologists were in support of medical cannabis use and 13.8 % have recommended it for a dermatologic condition. Atopic dermatitis (45 %) and psoriasis (40 %) were the most common. The most common form of administration was topical (75 %). The main reasons for not recommending medical cannabis were limited knowledge (56 %) and lack of experience (48 %).Yeroushalmi, S., Nelson, K., Sparks, A., & Friedman, A. (2021). Perceptions and recommendation behaviors of dermatologists for medical cannabis: A pilot survey. Journal of Drugs in Dermatology, 20(1), 74-78. https://pubmed.ncbi.nlm.nih.gov/33220620/
2025-10-17
What are the mechanisms in which THC and CBD impact pain sensation?
According to a British Medical Journal (BMJ) article, "THC inhibits glutamate and 5-hydroxytryptamine release and increases dopamine secretion. CBD enhances adenosine receptor signaling, and decreases reactive oxygen species, tumour necrosis factor, and T cell proliferation, without the psychoactive effects of THC. The multifaceted analgesic and anti-inflammatory properties of cannabinoids may positively influence the perception of pain across different conditions."Busse JW, Wang L, Kamaleldin M, et al. Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline. BMJ. 2021;374:n2040. doi:10.1136/bmj.n2040
2025-10-16
Can children with developmental and epileptic encephalopathies tolerate adjunctive cannabidiol (CBD) transdermal gel, and is CBD gel associated with reduced seizure frequency?
According to a JAMA Open Network article, in a "nonrandomized controlled trial, CBD transdermal gel was well tolerated over 6.5 months of treatment, with 60% of patients experiencing a treatment-related adverse event, 96% of which were mild or moderate. A 43.5% reduction in seizure frequency was observed in focal impaired awareness seizures and tonic-clonic seizures." Also, the researchers stated that "Parents and caregivers noted improvements in social or interpersonal engagement and irritability; alertness, energy, and sleep; and cognition or concentration."Scheffer IE, Hulihan J, Messenheimer J, et al. Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial. JAMA Netw Open. 2021;4(9):e2123930. doi:10.1001/jamanetworkopen.2021.23930 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783716
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