Could cannabinoid therapy modulate the wasting and cachexia associated with ALS?
A survey in ALS patients reported that cannabis was effective at reducing symptoms of appetite loss. The physiological control of appetite, feeding behavior and satiety is extremely complex, involving numerous neurotransmitters and neuropeptides. The current understanding suggests that there are many interactions between the ECS and multiple systems to modulate appetite stimulation. For example, endocannabinoids might interact with leptin, a hormone released from adipocytes, to modulate food intake. Studies suggest that people actively using cannabis have higher intakes of energy and nutrients than non-users and that exposure to cannabis correlates positively with an increase in food consumption, caloric intake, and body weight.