Metabolism of THC, CBD and CBN - The Answer Page

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A Nationally Approved CME/CE Medical Marijuana Course V2

A Nationally Approved CME/CE Medical Marijuana Course V2 CME/CE Information

"A Nationally Approved CME/CE Medical Marijuana Course V2”

A Nationally Approved CME/CE Medical Marijuana Course V2 Objectives

Introduction to the Endocannabinoid System and Phytocannabinoids

The Endocannabinoid System (ECS)

The Main Components of the ECS

Anandamide and 2-AG

Cannabinoid Receptor-1 (CB-1)

Cannabinoid Receptor-2 (CB-2)

Regulatory Enzymes of the ECS

The Cannabis Plant and the Major Phytocannabinoids

Cannabis, Marijuana and Hemp

Phytocannabinoids

Overview of Delta-9-tetrahydrocannabinol (THC)

Overview of Cannabidiol (CBD)

The Safety Profile of Cannabidiol (CBD)

CBD Influences the Side Effect Profile THC

The Chemical Structures of THC and CBD

The Pharmacological Properties of the Minor Phytocannabinoids

Cannabichromene (CBC)

Cannabigerol (CBG)

Tetrahydrocannabivarin (THCV)

Cannabinol (CBN)

Terpenes

QUIZ 1 -The Endocannabinoid System and Phytocannabinoids Quiz

Marijuana Products, Modes of Administration and Pharmacology

Marijuana Products

Smoking

Vaporizing

Vaporization Systems

Oral Administration

Edibles

Overconsumption

Oromucosal Spray

Rectal Administration

Topical Administration

Effects May Change Over Time

Interindividual Variation

Quiz 2-Marijuana Products, Modes of Administration and Pharmacokinetics Quiz

Precautions: The Use of Cannabinoid-based Drugs in Special Patient Populations

Patients with Psychotic Illness

Patients with Ischemic Heart Disease

Patients with Hepatic Disease

Patients with A History of Drug Abuse

Hypersensitivity Reactions

Pregnant Patients

Patients Who Are Breastfeeding

Pediatric Patients

Geriatric Patients

Risk of Falling

Quiz 3-Precautions: The Use of Cannabinoid-based Drugs in Special Patient Populations and Cannabinoid-based Drug Metabolism and Potential Cannabinoid-based Drug Interactions Quiz

Precautions: Cannabinoid-based Drug Metabolism and Potential Cannabinoid-based Drug Interactions

Metabolism of THC, CBD and CBN

Table of Drug: Drug Interactions

THC Inhibits CYP2C9

Pain Medications

Anti-coagulants and Other Medications Taken By Cardiac Patients

Medications with a Narrow Therapeutic Index

Anti-epileptic Medications

Psychiatric Medications

CNS Depressants

Smoking Marijuana Affects Drug Metabolism

CYP450 Isoenzyme Polymorphisms

Inhibitors of Cytochrome P450 Isoenzymes

Inducers of Cytochrome P450 Isoenzymes

Plasma Proteins

Quiz 4 – Cannabinoid-based Drug Metabolism and Potential Cannabinoid-based Drug Interactions

Physiologic and Cognitive Effects of Marijuana

Many Factors Influence the Effects of Marijuana

Neurologic Effects

The ECS Modulates Pain

A Common Neurologic Side Effect

Appetite and Metabolism

Nausea and Vomiting

The Gastrointestinal System

Inflammatory Bowel Disease

The Cardiovascular System

Myocardial Oxygen Consumption

Tolerance to Cardiovascular Effects

Pulmonary Function and Respiratory Drive

The Reproductive System

The Eye

Cancer

Tolerance to Psychologic and Somatic Effects

Quiz 5 – Physiologic and Cognitive Effects of Marijuana Quiz

A Nationally Approved CME/CE Medical Marijuana Course V2

Metabolism of THC, CBD and CBN

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