New York State Practitioner Education - Medical Use of Marijuana Course
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The Medical Use of Marijuana in Multiple Sclerosis

Note: See the spasticity module for discussion of spasticity in multiple sclerosis (MS).

The popularity of cannabis use among MS patients is likely explainable on the basis of the importance of the endocannabinoid system in the pathophysiology of the disease. CB1 receptors are integral in the control of muscle tone and tremor mechanisms (Baker et al., 2000), and both THC and CBD may inhibit neurodegeneration in the disorder, at least in animal models (Pryce et al., 2003).  This module will review the available clinical evidence for the use of cannabis in the treatment of multiple sclerosis.

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