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Question of the Day

What are the potential drug interactions between chemotherapy agents and nabilone, a synthetic cannabinoid used to treat nausea and vomiting associated with chemotherapy?

In clinical use, the very low nabilone plasma concentration is unlikely to interfere with the cytochrome P450-mediated degradation of co-administered drugs, however the nabilone product monograph cautions against administering nabilone in combination with any CNS depressant drugs. There is no mention of increased toxicity of anti-cancer drugs in the monograph, nonetheless prescribers should use caution when prescribing nabilone or other cannabinoids to patients undergoing cancer chemotherapy and/or taking anti-cancer drugs.