Course created by Meredith Fisher-Corn, M.D. and Stephen B. Corn, M.D.

Copyright © 2018 The Answer Page. All rights reserved.

Table of Contents

 

Syllabus Topic I

The Endocannabinoid System and Phytocannabinoids

Part 1

  • Endocannabinoid System (ECS)
    • Definition of the Endocannabinoid System
    • Components of the Endocannabinoid System
      • Endocannabinoids
        • N-arachidonoylethanolamine (also called anandamide)
        • 2-arachidonoylglycerol (2-AG)
      • Receptors
      • Regulatory Enzymes

Part 2

  • Pharmacology of Cannabis
    • Components of cannabis
      • Phytocannabinoids
        • Delta-9-tetrahydrocannabinol (THC)
        • Cannabidiol (CBD)
      • Terpenes
    • Interaction among phytocannabinoids
      • Entourage Effect

Part 3

  • Minor Phytocannabinoids
    • Cannabinol (CBN)
    • Cannabichromene (CBC)
    • Cannabigerol (CBG)
    • Tetrahydrocannabivarin (THCV)

 

Syllabus Topic II

The Administration and Dosing of Cannabis Products
(including contraindications, drug metabolism and drug interactions)

Part 1

  • The Approved Cannabis Products and the Approved Modes of Administration in New York State
    • Approved cannabis products and the approved modes of administration
    • The dispensing of cannabis products
    • The pharmacologic profile of vaporized cannabis
    • The pharmacologic profile of orally administered cannabis
    • The pharmacologic profile of oromucosally administered cannabis

Part 2

  • Cannabis Dosing
    • The reasons why there is no established set of guidelines for medical cannabis
    • Avoiding unwanted side effects
    • Lipophilicity of THC
    • Preventing the misuse of cannabis

Part 3

  • Contraindications to Medicinal Cannabis
    • Absolute contraindications to medicinal cannabis
    • Relative contraindications to medicinal cannabis
    • Specific precautions for the use of cannabinoids in pediatric and elderly populations
    • Absolute contraindications to cannabidiol (CBD) therapy

Part 4

  • The Metabolism of Cannabis and Potential Drug Interactions
    • The metabolism of cannabis
    • Potential drug interactions between chemotherapy agents and cannabinoid medicines
    • Potential drug interactions between antiretroviral medications and cannabinoid medicines
    • Potential drug interactions between analgesic medications and cannabinoid medicines
    • Potential drug interactions between anti-epileptic drugs and cannabidiol (CBD)
    • Cytochrome P450 inhibitors
    • Cytochrome P450 inducers

 

Syllabus Topic III

Physiological Effects and Adverse Effects of Cannabis

Part 1

  • Clinical Physiology of Cannabis
    • Effects on:
      • Central nervous system
      • Cardiovascular system

Part 2

  • Side Effects and Adverse Reactions I
    • Adverse Cannabis Reactions: cognition, pyschomotor performance, operating vehicles and machinery

Part 3

  • Side Effects and Adverse Reactions II
    • The relationship between exposure to cannabis and the development of psychosis and schizophrenia
    • The relationship between exposure to cannabis and the development of depression
    • The relationship between exposure to cannabis and the development of bipolar disorders
    • The relationship between exposure to cannabis and suicide

Part 4

  • Cannabis Use Disorder
    • Recognition
    • Diagnosis
    • Treatment
    • Strategies for risk evaluation
    • Mitigation of the disorder

Part 5

  • Cannabinoid Hyperemesis Syndrome
    • Diagnostic criteria
    • Laboratory markers of cannabinoid hyperemesis syndrome
    • A comparison of cannabinoid hyperemesis syndrome to cyclical vomiting syndrome