AOTD

What is the most common route of administration for the synthetic cannabinoids K2 or Spice? K2 and Spice are used for recreational purposes, and smoking is the most common route…

Does marijuana use alter the sexual intercourse experience? An online survey posed questions regarding various aspects of sexual experience and how those aspects were impacted by marijuana use. The results…

CB1 receptors are located on neurons in the CNS and PNS. Are CB1 receptors also located on cardiomyocytes? Yes. CB1 receptors are located in cardiomyocytes, vascular endothelial cells as well…

Some cannabinoid-based medicines are used to treat chemotherapy-induced n/v. Have cannabinoid-based medicines been shown to be effective in the treatment of post-op n/v? The results of studies indicate that neither…

Does ketamine interact with the endocannabinoid system? Yes. Ketamine induces the release of endocannabinoids. See Answer See Answer

Do CB1 and CB2 agonists facilitate endogenous opioid signaling? Yes. In fact, CB1 and CB2 agonists increase the concentrations of endogenous opioids. See Answer See Answer

Is the endocannabinoid system linked to the opioid system? Yes. Opioid receptors and CB receptors are located within the same neurons within the CNS. In addition, cannabinoids activate kappa and…

How do cannabinoids modulate pain sensation? In other words, describe the mechanism of action of cannabinoids. Endocannabinoids are synthesized in the postsynaptic neuron in response to stimuli such as pain,…

A study by Jamal et al. published in the European Journal of Anaesthesiology reported that marijuana users required a higher dose of morphine s/p abdominal surgery. They estimated that there…

CBD is a negative allosteric modulator. What does that mean? A negative allosteric modulator changes the shape of the receptor and, as a result, reduces the binding ability of components…