In Australia, many jurisdictions use point-of-collection oral fluid testing devices (the DrugWipe®-5S and the Drug Test® 5000) to detect driving under the influence of cannabis (which is indexed by the presence of Δ9-THC in oral fluid). Can these devices used in Australia reliably distinguish between CBD and THC, which have similar chemical structures? |
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Are CB2 receptors involved with pain modulation? |
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CB1 receptors are involved with the modulation of pain in the CNS. Do CB1 receptors modulate pain via another mechanism? |
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CB1 receptors are found throughout the central nervous system and some peripheral tissues. CB2 receptors are mainly found in peripheral tissues and immune cells. Are cannabinoid receptors found in organs involved with the production of sex hormones, too? |
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Do CB2 receptors play a role in diabetic neuropathy? |
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Does hyperglycemia impact expression of CB2 receptors in the glomerulus of the kidney? |
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Is chronic marijuana use associated with higher or lower fasting insulin levels? |
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Do endocannabinoids impact insulin release? |
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Have human studies evaluated the effects of cannabinoid consumption on cortisol levels? |
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Has the use of a transdermal gel for regional and systemic delivery of CBD been evaluated for the treatment of epilepsy? |
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Jeffrey Sherwood Block, M.D. . is a Board-certified physician anesthesiologist and adjunct Professor at the University of Miami Miller School of Medicine. Additionally, he is a highly awarded horticulturist and certified Master Gardener educator with the University of Florida’s UF/IFAS Extension Program. Dr. Block’s textbook chapter “Endocannabinoid Receptors and Medical Cannabis” (Advanced Therapeutics in Pain Medicine – CRC Press 2020) is a sentinel work on integrated pain management. Block served as the Florida Medical Association’s “Designated Expert on Botanical Medicines” authoring mandated physician education; and in 2014 was appointed by Florida’s Surgeon General to determine the rules for Florida’s first cannabis law. His consultancy’s demonstrated insight and responsible leadership are valued by both allied professionals and new industries seeking knowledge of future uses for Cannabinoid medicines.