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Today’s Answer of the Day

By AOTD
Question

As of January 2020, how many Americans were using marijuana-based products for medicinal purposes?

Today’s Answer of the Day

By AOTD
Question

Cannabinoids are metabolized by many of the same cytochrome P450 enzymes as warfarin, including CYP3A4, CYP2C9, and CYP2C19. THC, CBD and CBN can inhibit the CYP2C9-mediated hydroxylation of warfarin, and thus lead to an increase in INR. Do cannabinoids also affect the metabolism of heparin? Is the metabolism of direct oral anticoagulants (DOACs), including rivaroxaban, edoxaban, and apixaban, impacted by cannabinoids?

Today’s Answer of the Day

By AOTD
Question

CBD is a CB1 antagonist and a negative allosteric modulator at CB2. Does CBD interact with receptors other than CB1 or CB2?

Today’s Answer of the Day

By AOTD
Question

Cannabinoid receptors are located throughout various parts of the CNS, including the basal ganglia, hippocampus, cerebellum and cerebral cortex, and in the peripheral nervous system. Also, CB2 receptors are located on cells in the immune system. Do these receptors have effects on neurotransmitters such as serotonin?

Today’s Answer of the Day

By AOTD
Question

Methadone, morphine and heroin are all narcotics. Do they all have a similar chemical structure?